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Interesting seminar taking place in the JA building next week. See
below.<br>
<br>
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<div style="direction: ltr;font-family: Arial;color:
#000000;font-size: 10pt;">Dear all,
<div><br>
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<div>Professor Fu-Jen Kao from National Yang-Ming University,
Taipei, will give a seminar on Thursday 4th August. The
seminar will take place in JA5.06 from 12noon-1pm. Details
below, and all are welcome.</div>
<div><br>
</div>
<div><b style="font-size: small;"><span lang="EN-US">Stimulated
</span></b><b style="font-size: small;"><span lang="EN-US">E</span></b><b
style="font-size: small;"><span lang="EN-US">mission
</span></b><b style="font-size: small;"><span lang="EN-US">B</span></b><b
style="font-size: small;"><span lang="EN-US">ased
</span></b><b style="font-size: small;"><span lang="EN-US">F</span></b><b
style="font-size: small;"><span lang="EN-US">luorescence
</span></b><b style="font-size: small;"><span lang="EN-US">D</span></b><b
style="font-size: small;"><span lang="EN-US">etection</span></b></div>
<div>
<p class="SPIEAuthors-Affils"><font size="2"><b><span
lang="EN-US">I-Che Chen, Chun-Hui Yu</span></b><b><span
lang="EN-US">, and Fu-Jen Kao*<o:p></o:p></span></b></font></p>
<p class="MsoNormal" style="text-align: left; margin-left:
13.6pt; text-indent: -13.6pt;" align="center">
<font size="2"><i><span lang="EN-US">Institute of Biopho</span></i><i><span
lang="EN-US">to</span></i><i><span lang="EN-US">nics,
National Yang-Ming University,
</span></i><i><span lang="EN-US">Taipei 11221, Taiwan,
ROC</span></i><i><span lang="EN-US">
</span></i><b><span lang="EN-US"><o:p></o:p></span></b></font></p>
<p class="MsoNormal"
style="text-align:center;mso-char-indent-count:
-1.7" align="center">
<span style="font-size: small;"> </span></p>
<p class="MsoNormal" style="margin-left:0cm;text-indent:0cm"><font
size="2"><span lang="EN-US">Fluorescence is widely used in
biomedical imaging. It allows
</span><span lang="EN-US">specific </span><span
lang="EN-US">label</span><span lang="EN-US">ing</span><span
lang="EN-US"> and target</span><span lang="EN-US">ing</span><span
lang="EN-US">
</span><span lang="EN-US">with</span><span lang="EN-US">
molecul</span><span lang="EN-US">ar sensitivity</span><span
lang="EN-US"> through immunocytochemistr</span><span
lang="EN-US">y</span><span lang="EN-US">.</span><span
lang="EN-US">
</span><span lang="EN-US">However, </span><span
lang="EN-US">it</span><span lang="EN-US"> is incoherent
and emits in all directions</span><span lang="EN-US">.</span><span
lang="EN-US">
</span><span lang="EN-US">Henceforth</span><span
lang="EN-US"> its intensity decreases
</span><span lang="EN-US">rapidly and </span><span
lang="EN-US">inversely with the square of the distance</span><span
lang="EN-US"> and</span><span lang="EN-US"> would
require high numerical aperture (NA) optics</span><span
lang="EN-US"> for efficient</span><span lang="EN-US">
collect</span><span lang="EN-US">ion</span><span
lang="EN-US">. This problem can be
</span><span lang="EN-US">remedied</span><span
lang="EN-US"> by </span><span lang="EN-US">stimulated
emission (SE) based fluorescence detection that
</span><span lang="EN-US">would </span><span lang="EN-US">maintain
the molecule specific contrast through
</span><span lang="EN-US">immuno-labeling </span><span
lang="EN-US">while</span><span lang="EN-US">
</span><span lang="EN-US">convert</span><span lang="EN-US">ing</span><span
lang="EN-US"> the incoherent spontaneous fluorescence
signal into a
</span><span lang="EN-US">stimulated and </span><span
lang="EN-US">coherent one. </span>
<span lang="EN-US">We had demonstrated </span><span
lang="EN-US">stimulated emission (SE) imaging
</span><span lang="EN-US">in</span><span lang="EN-US"> </span><span
lang="EN-US">a
</span><span lang="EN-US">long-working distance </span><span
lang="EN-US">configuration. Additionally, the
</span><span lang="EN-US">fluorescence lifetime imaging </span><span
lang="EN-US">is realized
</span><span lang="EN-US">by </span><span lang="EN-US">electroni</span><span
lang="EN-US">cally controlling the</span><span
lang="EN-US"> time delay between
</span><span lang="EN-US">the </span><span lang="EN-US">excitation
and </span><span lang="EN-US">the
</span><span lang="EN-US">SE pulses in the nanosecond
ranges</span><span lang="EN-US">
</span><span lang="EN-US">through pump-probe
configuration.</span><span lang="EN-US">
</span><span lang="EN-US">However, the depth resolution is
sacrificed </span><span lang="EN-US">due to</span><span
lang="EN-US"> low NA
</span><span lang="EN-US">optics in such a configuration</span><span
lang="EN-US">. In order to
</span><span lang="EN-US">take advantage of</span><span
lang="EN-US"> the optical coherence of SE and
</span><span lang="EN-US">obtain the</span><span
lang="EN-US"> </span><span lang="EN-US">corresponding
</span><span lang="EN-US">depth information</span><span
lang="EN-US">,</span><span lang="EN-US">
</span><span lang="EN-US">interferometric</span><span
lang="EN-US"> techniques </span>
<span lang="EN-US">are</span><span lang="EN-US">
incorporated.</span><span lang="EN-US"> We have obtained
a resolution of 66 mm, which depends on the coherence
length of the stimulation beam.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="margin-left:0cm;text-indent:0cm"><span
lang="EN-US"><font size="2"> </font></span></p>
<p class="MsoNormal" style="margin-left: 0cm; text-indent:
0cm;" align="left"><br>
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<div style="font-family:Tahoma; font-size:13px">
<div><font face="Arial" size="2">--------------------------------------------------</font></div>
<div><font face="Arial" size="2">Professor Gail McConnell</font></div>
<div><font face="Arial" size="2">Centre for Biophotonics</font></div>
<div><font face="Arial" size="2">SIPBS Building,
University of Strathclyde</font></div>
<div><font face="Arial" size="2">161 Cathedral Street</font></div>
<div><font face="Arial" size="2">Glasgow G4 0RE</font></div>
<div> </div>
<div><font face="arial" size="2">Tel: 00 44 141 548 4805</font></div>
<div><font face="Arial" size="2">Email:
<a class="moz-txt-link-abbreviated" href="mailto:g.mcconnell@strath.ac.uk">g.mcconnell@strath.ac.uk</a></font></div>
<div><font face="arial" size="2">--------------------------------------------------</font></div>
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