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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D">SENT ON BEHALF OF PROF. GAIL MCCONNELL<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black">Dear all,
<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black">Professor Fu-Jen Kao from National Yang-Ming University, Taipei, will give a seminar on Thursday 4th August. The seminar will take place in JA5.06 from 12noon-1pm.
Details below, and all are welcome.<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black"><o:p> </o:p></span></p>
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<p class="MsoNormal"><b><span lang="EN-US" style="font-family:"Arial","sans-serif";color:black">Stimulated Emission Based Fluorescence Detection</span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black"><o:p></o:p></span></p>
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<p class="spieauthors-affils"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black">I-Che Chen, Chun-Hui Yu, and Fu-Jen Kao*</span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black"><o:p></o:p></span></p>
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<i><span lang="EN-US" style="font-size:10.0pt;color:black">Institute of Biophotonics, National Yang-Ming University, Taipei 11221, Taiwan, ROC</span></i><span style="color:black"><o:p></o:p></span></p>
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<span style="color:black"> <o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="font-size:10.0pt;color:black">Fluorescence is widely used in biomedical imaging. It allows specific labeling and targeting with molecular sensitivity through
immunocytochemistry. However, it is incoherent and emits in all directions. Henceforthits intensity decreases rapidly and inversely with the square of the distance and would require high numerical aperture (NA) optics for efficient collection. This problem
can be remedied by stimulated emission (SE) based fluorescence detection that would maintain the molecule specific contrast throughimmuno-labeling while converting the incoherent spontaneous fluorescence signal into a stimulated andcoherent one. We had demonstrated stimulated
emission (SE) imaging in a long-working distanceconfiguration. Additionally, the fluorescence lifetime imaging is realized by electronically controlling thetime delay between the excitation and the SE pulses in the nanosecond ranges through pump-probe configuration. However,
the depth resolution is sacrificed due to low NA optics in such a configuration. In order to take advantage of the optical coherence of SE and obtain the corresponding depth information,interferometric techniques are incorporated. We have obtained a resolution
of 66 mm, which depends on the coherence length of the stimulation beam.</span><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="color:black"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black">--------------------------------------------------</span><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif";color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black">Professor Gail McConnell</span><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif";color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black">Centre for Biophotonics</span><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif";color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black">SIPBS Building, University of Strathclyde</span><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif";color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black">161 Cathedral Street</span><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif";color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black">Glasgow G4 0RE</span><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif";color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif";color:black"> <o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black">Tel: 00 44 141 548 4805</span><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif";color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black">Email:
<a href="mailto:g.mcconnell@strath.ac.uk">g.mcconnell@strath.ac.uk</a></span><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif";color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:black">--------------------------------------------------</span><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif";color:black"><o:p></o:p></span></p>
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