[Postgrad] Seminar

[Shirley Wylie]

Dear all,

Professor Stuart Reid, Department of Biomedical Engineering, University of Strathclyde, will give a seminar at 13:00 on 18th January, in JA5.05. Please find below details, all welcome.

Thanks,

Gail

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Use of nanovibrational stimulation ("nanokicking") to control cell behaviour and stem cell differentiation
Professor Stuart Reid, Department of Biomedical Engineering, University of Strathclyde
13:00-14:00, 18th January 2019
JA5.05

The ability to control cell behaviour and cell fate remains a significant challenge within various fields of medical research, such as for manufacturing engineered tissues and for drug discovery.  The use of mechanotransduction (how cells convert mechanical forces to biochemical cues) could provide an alternative route for providing high quality controlled/specialised cells without the requirement for chemical induction factors or complex cell scaffolds.  Measurement and analytical techniques developed within the field of gravitational wave astronomy have recently been used to develop a novel technique for cell stimulation based on nanoscale vibration, referred to as "nanokicking".  The technique has been demonstrated to differentiate a potential autologous cell source, mesenchymal stem cells (MSCs), into mineralized tissue in 3D.  This could provide a new route for providing autologous bone grafts, which are currently in short supply, and are currently associated with pain and donor-site morbidity.  In addition, other cell responses include the promotion of cell fusion in placental cell lines, in addition to modifying biofilm deposition from bacteria (P. aeruginosa), suggesting that the response to nanoscale vibration is applicable to a wider range of cell types in addition to potentially being established early in evolutionary history. The development of the current hardware for supplying nanoscale vibrations to cell cultures (all designed and manufactured in Strathclyde) and an overview of cell responses, is discussed.



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